An in silico analysis of T-box regulated genes and T-box evolution in prokaryotes with emphasis on prediction of substrate specificity of transporters

摘要

BackgroundT-box anti-termination is an elegant and sensitive mechanism by which many bacteria maintain constant levels of amino acid-charged tRNAs. The amino acid specificity of the regulatory element is related to a so-called specifier codon and can in principle be used to guide the functional annotation of the genes controlled via the T-box anti-termination mechanism.