Immunosenescence of the CD8+ T cell compartment is associated with HIV-infection but only weakly reflects age-related processes of adipose tissue metabolism and muscle in antiretroviral therapy-treated HIV-infected patients and controls

摘要

BackgroundDespite effective antiretroviral therapy (ART), HIV-infected patients exhibit systemic inflammation, early onset of age-related diseases, and features of immunosenescence. The role of inflammation in the development of age-related diseases is widely recognized. However, the role of immunosenescence is not well established. Studying immunosenescence in HIV-infection could give insight into its role in ageing processes. In this cross-sectional study, we aimed to investigate whether ART-treated HIV-infected patients exhibit immunosenescence; and whether immunosenescence is associated with age-related processes of inflammation, metabolism, adipose tissue, and muscle. T cell immunosenescence and exhaustion were assessed by flow cytometry analysis of CD8^>+ cells from 43 ART-treated HIV-infected patients (HIV⁺) and ten Controls using markers of differentiation: CD27/CD28; maturation: CD27/CD45RA; senescence: killer cell lectin-like receptor G1 (KLRG1); and exhaustion: programmed death-1 (PD-1). Relationships between CD8^>+ T cell immunosenescence, exhaustion, and age-related processes were assessed using linear regressions.