A cluster randomised controlled trial of two rounds of mass drug administration in Zanzibar a malaria pre-elimination setting—high coverage and safety but no significant impact on transmission

摘要

BackgroundMass drug administration (MDA) has the potential to interrupt malaria transmission and has been suggested as a tool for malaria elimination in low-endemic settings. This study aimed to determine the effectiveness and safety of two rounds of MDA in Zanzibar, a pre-elimination setting.