Reducing the probability of false positive research findings by pre-publication validation – Experience with a large multiple sclerosis database

摘要

BackgroundPublished false positive research findings are a major problem in the process of scientific discovery. There is a high rate of lack of replication of results in clinical research in general, multiple sclerosis research being no exception. Our aim was to develop and implement a policy that reduces the probability of publishing false positive research findings.We have assessed the utility to work with a pre-publication validation policy after several years of research in the context of a large multiple sclerosis database.