The cross-pathway control system regulates production of the secondary metabolite toxin sirodesmin PL in the ascomycete Leptosphaeria maculans

摘要

BackgroundSirodesmin PL is a secondary metabolite toxin made by the ascomycetous plant pathogen, Leptosphaeria maculans. The sirodesmin biosynthetic genes are clustered in the genome. The key genes are a non-ribosomal peptide synthetase, sirP, and a pathway-specific transcription factor, sirZ. Little is known about regulation of sirodesmin production.