Housekeeping while brains storming Validation of normalizing factors for gene expression studies in a murine model of traumatic brain injury

摘要

BackgroundTraumatic brain injury models are widely studied, especially through gene expression, either to further understand implied biological mechanisms or to assess the efficiency of potential therapies. A large number of biological pathways are affected in brain trauma models, whose elucidation might greatly benefit from transcriptomic studies. However the suitability of reference genes needed for quantitative RT-PCR experiments is missing for these models.