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美国卫生研究院文献>BMC Musculoskeletal Disorders
>Coordinate and synergistic effects of extensive treadmill exercise and ovariectomy on articular cartilage degeneration
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Coordinate and synergistic effects of extensive treadmill exercise and ovariectomy on articular cartilage degeneration
BackgroundAlthough osteoarthritis (OA) is a multifactorial disease, little has been reported regarding the cooperative interaction among these factors on cartilage metabolism. Here we examined the synergistic effect of ovariectomy (OVX) and excessive mechanical stress (forced running) on articular cartilage homeostasis in a mouse model resembling a human postmenopausal condition.
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