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Thymosin β4 alleviates renal fibrosis and tubular cell apoptosis through TGF-β pathway inhibition in UUO rat models

机译：胸腺素β4通过抑制UUO大鼠模型中的TGF-β途径减轻肾脏纤维化和肾小管细胞凋亡

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摘要

BackgroundThymosin β4 (Tβ4) is closely associated with the cytoskeleton, inflammation, wound healing, angiogenesis, apoptosis, and myocardial regeneration, but the effects of Tβ4 treatment on chronic renal tubular interstitial fibrosis (CRTIF) are poorly known. This study aimed to examine the effects of Tβ4 on the renal apoptosis and the expression of transforming growth factor (TGF-β), E-cadherin, and α-smooth muscle actin (α-SMA) in CRTIF rat models.

机译：背景胸腺素β4（Tβ4）与细胞骨架，炎症，伤口愈合，血管生成，细胞凋亡和心肌再生密切相关，但是Tβ4治疗对慢性肾小管间质纤维化（CRTIF）的影响知之甚少。这项研究旨在检查Tβ4对CRTIF大鼠模型中肾脏凋亡以及转化生长因子（TGF-β），E-钙粘着蛋白和α-平滑肌肌动蛋白（α-SMA）表达的影响。

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期刊名称 BMC Nephrology
作者
Jing Yuan; Yan Shen; Xia Yang; Ying Xie; Xin Lin; Wen Zeng; Yingting Zhao; Maolu Tian; Yan Zha;
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作者单位

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年(卷),期 2017(18),-1
年度 2017
页码 314
总页数 10
原文格式 PDF
正文语种
中图分类泌尿科学（泌尿生殖系疾病）;小儿泌尿科学;肾疾病;
关键词
Thymosin β4 Transforming growth factorβ Renal fibrosis Cell apoptosis;

机译：胸腺素β4;转化生长因子β;肾纤维化;细胞凋亡;

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专利

1. Thymosin β4 alleviates renal fibrosis and tubular cell apoptosis through TGF-β pathway inhibition in UUO rat models [J] . Jing Yuan, Yan Shen, Xia Yang, BMC Nephrology . 2017,第1期

机译：胸腺素β4通过抑制UUO大鼠模型中的TGF-β途径减轻肾脏纤维化和肾小管细胞凋亡
2. Low-dose paclitaxel ameliorates renal fibrosis in rat UUO model by inhibition of TGF-|[beta]||[sol]|Smad activity [J] . Dongshan Zhang, Lin Sun, Wang xian, Laboratory investigation . 2010,第3期

机译：低剂量紫杉醇通过抑制TGF- |β|| [sol] | Smad活性改善大鼠UUO模型的肾纤维化
3. Extracellular vesicles produced by bone marrow mesenchymal stem cells attenuate renal fibrosis, in part by inhibiting the RhoA/ROCK pathway, in a UUO rat model [J] . Zhengzhou Shi, Qi Wang, Youbo Zhang, Stem Cell Research & Therapy . 2020,第1期

机译：通过骨髓间充质干细胞产生的细胞外囊泡在UUO大鼠模型中抑制RhoA /岩石途径，部分骨髓间充质干细胞衰减肾纤维化。
4. Targeting of kinase inhibitor-LZM conjugates to proximal tubular epithelial cells for local treatment of renal fibrosis [C] . Annual meeting exposition of the Controlled Release Society . 2009

机译：激酶抑制剂-LZM缀合物的靶向肾纤维化局部治疗近端管状上皮细胞
5. Inhibition of compensatory survival and proliferative pathway activation induced by mtor inhibition in renal cell carcinoma. [D] . Bailey, Sean Thomas. 2014

机译：抑制mtor抑制在肾细胞癌中诱导的代偿性存活和增殖途径激活。
6. Rhubarb and Astragalus Capsule Attenuates Renal Interstitial Fibrosis in Rats with Unilateral Ureteral Obstruction by Alleviating Apoptosis through Regulating Transforming Growth Factor beta1 (TGF-β1)/p38 Mitogen-Activated Protein Kinases (p38 MAPK) Pathway [O] . Xian Zeng, Guozhen Cai, Taolin Liang, 2020

机译：大黄和黄芪胶囊通过调节转化生长因子β1（TGF-β1）/ p38丝裂原活化蛋白激酶（p38 MAPK）的途径减轻细胞凋亡从而减轻单侧输尿管梗阻大鼠的肾间质纤维化。
7. Thymosin β4 alleviates renal fibrosis and tubular cell apoptosis through TGF-β pathway inhibition in UUO rat models [O] . Jing Yuan, Yan Shen, Xia Yang, 2017

机译：胸腺素β4通过UUO大鼠模型中的TGF-β途径抑制来减轻肾纤维化和管状细胞凋亡

Thymosin β4 alleviates renal fibrosis and tubular cell apoptosis through TGF-β pathway inhibition in UUO rat models

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