BackgroundMicro-Electrode Array (MEA) technology allows researchers to perform long-term non-invasive neuronal recordings in-vitro while actively interacting with the cultured neurons. Despite numerous studies carried out using MEAs, many functional, chemical and structural mechanisms of how dissociated cortical neurons develop and respond to external stimuli are not yet well understood because of the lack of quantitative studies that assess how their development can be affected by chronic external stimulation.
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