mGluR5‐dependent modulation of dendritic excitability in CA1 pyramidal neurons mediated by enhancement of persistent Na+ currents

摘要

Key points class="unordered" style="list-style-type:disc" id="tjp13064-list-0001">High‐frequency stimulation (HFS) of the Schaffer collateral pathway activates metabotropic glutamate receptor 5 (mGluR5) signalling in the proximal apical dendrites of CA1 pyramidal neurons.The synaptic activation of mGluR5‐mediated calcium signalling causes a significant increase in persistent sodium current (I Na,P) in the dendrites.Increased I Na,P by HFS underlies potentiation of synaptic inputs at both the proximal and distal dendrite, leading to an enhanced probability of action potential firing associated with decreased action potential thresholds.Therefore, HFS‐induced activation of intracellular mGluR5 serves an important role as an instructive signal for potentiation of upcoming inputs by increasing dendritic excitability.