Spinal dorsal horn astrocytes release GABA in response to synaptic activation

机译：脊髓背角星形胶质细胞释放GABA响应突触激活

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Key points class="unordered" style="list-style-type:disc" id="tjp13185-list-0001">GABA is an essential molecule for sensory information processing. It is usually assumed to be released by neurons.Here we show that in the dorsal horn of the spinal cord, astrocytes respond to glutamate by releasing GABA.Our findings suggest a novel role for astrocytes in somatosensory information processing.

机译：关键点 class =“ unordered” style =“ list-style-type：disc” id =“ tjp13185-list-0001”> <！-list-behavior = unordered prefix-word = mark-type = disc max- label-size = 0-> GABA是感觉信息处理中必不可少的分子。通常假定它是由神经元释放的。在这里，我们显示了在脊髓的背角，星形胶质细胞通过释放GABA来响应谷氨酸。我们的发现表明这是一种新型星形胶质细胞在体感信息处理中的作用。

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期刊名称 The Journal of Physiology
作者
Rasmus Kordt Christensen; *; Rodolfo Delgado‐Lezama; Raúl E. Russo; Barbara Lykke Lind; Emanuel Loeza Alcocer; Martin Fredensborg Rath; Gabriela Fabbiani; Nicole Schmitt; Martin Lauritzen; Anders Victor Petersen; Eva Meier Carlsen; Jean‐François Perrier;
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作者单位

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年(卷),期 2018(596),20
年度 2018
页码 4983–4994
总页数 12
原文格式 PDF
正文语种
中图分类神经科学;人体生理学;
关键词
astrocyte GABA spinal cord;

机译：星形胶质细胞;GABA;脊髓;

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专利

1. Spinal dorsal horn astrocytes release GABA in response to synaptic activation [J] . Christensen Rasmus Kordt, Delgado‐Lezama Rodolfo, Russo Raúl E., The Journal of Physiology . 2018,第20期

机译：脊髓背角星形胶质细胞释放GABA响应突触激活
2. Activation of toll like receptor 4 attenuates GABA synthesis and postsynaptic GABA receptor activities in the spinal dorsal horn via releasing interleukin-1 beta [J] . Xisheng Yan, Enshe Jiang, Han-Rong Weng Journal of neuroinflammation . 2015,第3期

机译：Toll样受体4的激活通过释放白介素1β减弱了脊髓背角中GABA的合成和突触后GABA受体的活性。
3. mTOR PATHWAY IS INVOLVED IN ADP-EVOKED ASTROCYTE ACTIVATION AND ATP RELEASE IN THE SPINAL DORSAL HORN IN A RAT NEUROPATHIC PAIN MODEL [J] . J. CUI, W. HE, B. YI, Neuroscience: An International Journal under the Editorial Direction of IBRO . 2014,第Null期

机译：大鼠神经病理性疼痛模型中脊髓后背角的ADP诱发的星形胶质细胞活化和ATP释放涉及mTOR通路
4. Cellular Mechanisms for the Enhancement by Bee Venom Melittin of GABAergic and Glycinergic Inhibitory Synaptic Transmission in Adult Rat Spinal Dorsal Horn Neurons [C] . Tao Liu, Tsugumi Fujita, Hai-Yuan Yue Japanese peptide symposium . 2010

机译：大鼠脊髓背角神经元的甘草能和甘油池抑制突触突触突出的蜂毒液肌肽增强细胞机制
5. Modulation of gamma-aminobutyric acid (GABA) type A receptor-mediated responses in spinal dorsal horn neurons by mu-opioid receptor agonists and calcium(2+)/calmodulin-dependent protein kinase and Monte Carlo simulation of the GABAergic synaptic transmission. [D] . Wang, Rong. 1995

机译：γ-氨基丁酸（GABA）A型受体介导的mu阿片类受体激动剂和钙（2 +）/钙调蛋白依赖性蛋白激酶和Monte Carlo模拟的GABA能突触传递的脊髓背角神经元。
6. Activation of toll like receptor 4 attenuates GABA synthesis and postsynaptic GABA receptor activities in the spinal dorsal horn via releasing interleukin-1 beta [O] . Xisheng Yan, Enshe Jiang, Han-Rong Weng 2015

机译：Toll样受体4的激活通过释放白介素1β减弱了脊髓背角中GABA的合成和突触后GABA受体的活性。
7. Spinal dorsal horn astrocytes release GABA in response to synaptic activation [O] . Rasmus Kordt Christensen, Rodolfo Delgado-Lezama, Raúl E. Russo, 2018

机译：脊髓背角星形胶质细胞释放GABA响应突触激活
8. Effects of Chemotherapy on Astrocyte Density in the Rat Spinal Cord Dorsal Funiculi after Stab-wound Lesion: I. 5-Fluorouracil. II. Alphamethyl-tyrosine. III. Dexamethasone. IV. Simultaneous dexamethasone and 5-Fluorouracil. [R] . Grim, J. N. 1976

机译：化疗对大鼠脊髓损伤后脊髓背侧星形胶质细胞密度的影响：I。5-氟尿嘧啶。 II。 α-甲基酪氨酸。 III。地塞米松。 IV。同时使用地塞米松和5-氟尿嘧啶。

Spinal dorsal horn astrocytes release GABA in response to synaptic activation

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