Comparison of next-generation sequencing samples using compression-based distances and its application to phylogenetic reconstruction

摘要

BackgroundEnormous volumes of short read data from next-generation sequencing (NGS) technologies have posed new challenges to the area of genomic sequence comparison. The multiple sequence alignment approach is hardly applicable to NGS data due to the challenging problem of short read assembly. Thus alignment-free methods are needed for the comparison of NGS samples of short reads.