Feature selection and validated predictive performance in the domain of Legionella pneumophila: a comparative study

摘要

BackgroundGenetic comparisons of clinical and environmental Legionella strains form an essential part of outbreak investigations. DNA microarrays often comprise many DNA markers (features). Feature selection and the development of prediction models are particularly challenging in this domain with many variables and comparatively few subjects or data points. We aimed to compare modeling strategies to develop prediction models for classifying infections as clinical or environmental.