Determinants of human cerebral pressure–flow velocity relationships: new insights from vascular modelling and Ca2+ channel blockade

摘要

Non-technical summaryBrain function is critically dependent on the regulation of cerebral blood flow (CBF) by cerebral blood vessels. We show that a mechanical blood vessel property called compliance plays an important role in determining the way cerebral blood vessels respond to changes in blood pressure. These results enhance our knowledge of how cerebral blood vessels regulate CBF, which is critical to understanding the causes and effects of cerebrovascular diseases such as stroke and dementia.