Exploring the use and impact of adjuvant Trastuzumab for HER2-positive breast cancer patients in a large UK cancer networkDo the results of international clinical trials translate into a similar benefit for patients in South East Wales?

摘要

Background: Trastuzumab was approved in the United Kingdom for adjuvant treatment of human epidermal growth factor receptor 2 (HER2)+ breast cancer in 2006 at significant economic cost and with limited evidence in smaller T1N0 tumours. The South East Wales Cancer Network covers a population of 1 420 000 and maintains a database of treatments used. We examined this database to ensure the outcome of Trastuzumab use is as expected, especially in patients with T1N0 cancers.