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A phase I trial of pan-Bcl-2 antagonist obatoclax administered as a 3-h or a 24-h infusion in combination with carboplatin and etoposide in patients with extensive-stage small cell lung cancer

机译：泛Bcl-2拮抗剂obatoclax的3期或24小时输注与卡铂和依托泊苷联用的I期试验在广泛期小细胞肺癌患者中的应用

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摘要

Background: Bcl-2 family genes are frequently amplified in small cell lung cancer (SCLC). A phase I trial was conducted to evaluate the safety of obatoclax, a Bcl-2 family inhibitor, given in combination with standard chemotherapy.

机译：背景：Bcl-2家族基因在小细胞肺癌（SCLC）中经常扩增。进行了一项I期试验，以评估与标准化学疗法联合给予的Bcl-2家族抑制剂obatoclax的安全性。

著录项

期刊名称 British Journal of Cancer
作者
A A Chiappori; M T Schreeder; M M Moezi; J J Stephenson; J Blakely; R Salgia; Q S Chu; H J Ross; D S Subramaniam; J Schnyder; M S Berger;
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作者单位

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年(卷),期 2012(106),5
年度 2012
页码 839–845
总页数 7
原文格式 PDF
正文语种
中图分类肿瘤学 ;
关键词
small cell lung cancer apoptosis Bcl-2 gene family CNS symptoms;

机译：小细胞肺癌;凋亡;Bcl-2基因家族;中枢神经系统症状;

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1. A phase I trial of pan-Bcl-2 antagonist obatoclax administered as a 3-h or a 24-h infusion in combination with carboplatin and etoposide in patients with extensive-stage small cell lung cancer [J] . A A Chiappori, M T Schreeder, M M Moezi, British Journal of Cancer . 2012 ,第5期

机译：泛Bcl-2拮抗剂obatoclax的3期或24小时输注与卡铂和依托泊苷联用的I期试验在广泛期小细胞肺癌患者中的应用
2. Randomized phase II study of carboplatin and etoposide with or without obatoclax mesylate in extensive-stage small cell lung cancer. [J] . Corey J Langer, Istvan Albert, Helen J Ross, Lung cancer: Journal of the International Association for the Study of Lung Cancer . 2014 ,第3期

机译：卡铂和依托泊苷加或不加甲磺酸奥托巴克斯治疗广泛期小细胞肺癌的随机II期研究。
3. Randomized phase II study of carboplatin and etoposide with or without obatoclax mesylate in extensive-stage small cell lung cancer. [J] . Corey J Langer, Istvan Albert, Helen J Ross, Lung cancer: Journal of the International Association for the Study of Lung Cancer . 2014 ,第3期

机译：在广泛阶段的小细胞肺癌中，随机分子II研究，有或没有Obatoclax甲磺酸盐的甲磺酸盐。
4. The Combination of Clinical, Dose-Related and Imaging Features Helps Predict Radiation-Induced Normal-Tissue Toxicity in Lung-cancer Patients -- An in-silico Trial Using Machine Learning Techniques [C] . Nalbantov G., Dekker A., De Ruysscher D., Machine Learning and Applications and Workshops (ICMLA), 2011 10th International Conference on . 2011

机译：临床，剂量相关和影像学特征的结合可帮助预测肺癌患者放射诱发的正常组织毒性-使用机器学习技术的计算机模拟试验
5. Safety and Efficacy of the Immunomodulatory Drug (IMiD) Lenalidomide in Patients with Lymphoma: Development of RU051417I - Phase I/II Open-Label Study of R-ICE (Rituximab-Ifosfamide-Carboplatin-Etoposide) with Lenalidomide [R2-ICE] in Patients with First-Relapse/Primary Refractory Diffuse Large B-Cell Lymphoma (DLBCL). [D] . Kasi, Pashtoon Murtaza. 2018

机译：免疫调节药物来那度胺在淋巴瘤患者中的安全性和有效性：RU051417I-R-ICE（利妥昔单抗-异环磷酰胺-卡铂-依托泊苷）与来那度胺[R2-ICE]的I / II期开放标签研究的进展初次复发/原发性难治性弥漫性大B细胞淋巴瘤（DLBCL）。
6. Prognostic and predictive value of circulating tumor cells and CXCR4 expression as biomarkers for a CXCR4 peptide antagonist in combination with carboplatin-etoposide in small cell lung cancer: exploratory analysis of a phase II study [O] . Ravi Salgia, R. Waide Weaver, Michael McCleod, -1

机译：循环肿瘤细胞和CXCR4表达作为CXCR4肽拮抗剂联合卡铂-依托泊苷在小细胞肺癌中的生物标志物的预后和预测价值：II期研究的探索性分析
7. A phase I trial of pan-Bcl-2 antagonist obatoclax administered as a 3-h or a 24-h infusion in combination with carboplatin and etoposide in patients with extensive-stage small cell lung cancer [O] . A A Chiappori, M T Schreeder, M M Moezi, 2012

机译：泛Bcl-2拮抗剂Obatoclax的I阶段试验作为3-h或24-h输注，与Carboplatin和依托泊苷中的广泛阶段小细胞肺癌患者组合

A phase I trial of pan-Bcl-2 antagonist obatoclax administered as a 3-h or a 24-h infusion in combination with carboplatin and etoposide in patients with extensive-stage small cell lung cancer

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