Downregulation of membrane complement inhibitors CD55 and CD59 by siRNA sensitisesuterine serous carcinoma overexpressing Her2eu to complement and antibody-dependentcell cytotoxicity in vitro: implications for trastuzumab-basedimmunotherapy

摘要

Background: We evaluated the expression of CD46, CD55 and CD59 membrane-bound complement-regulatory proteins (mCRPs) in primary uterine serous carcinoma (USC) and the ability of small interfering RNA (siRNA) against these mCRPs to sensitise USC to complement-dependent cytotoxicity (CDC) and antibody (trastuzumab)-dependent cellular cytotoxicity (ADCC) in vitro.