A double blind, prospective study was undertaken to compare aqueous humour penetration of topical 0.3% norfloxacin and 0.3% ciprofloxacin and their effect upon normal eyelid flora in 39 patients undergoing cataract surgery. Lid swabs were taken before and after six 1 hourly applications of single drops of ciprofloxacin or norfloxacin given before surgery. Aqueous humour was aspirated at surgery and antibiotic concentration assayed using high performance liquid chromatography. The mean aqueous humour concentrations were: ciprofloxacin 220 ng ml-1, norfloxacin 140 ng ml-1. Although this difference was not statistically significant (p = 0.112) the trend demonstrated may be relevant clinically, especially considering the greater activity of ciprofloxacin. Both coagulase negative staphylococcal (p = 0.004) and total bacterial (p = 0.019) lid counts dropped sixfold after ciprofloxacin treatment but the smaller reductions noted after norfloxacin application did not achieve statistical significance (p > 0.1). The reduction of external eye flora experienced with ciprofloxacin suggests that this may be a useful presurgical prophylactic agent.
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机译：进行了一项双盲前瞻性研究，以比较39例接受白内障手术的患者局部房水渗透率0.3％诺氟沙星和0.3％环丙沙星及其对正常眼睑菌群的影响。术前每滴1滴环丙沙星或诺氟沙星六次，每次1小时之前和之后，取盖拭子。在手术中抽吸房水，并使用高效液相色谱法测定抗生素浓度。房水的平均浓度为：环丙沙星220 ng ml-1，诺氟沙星140 ng ml-1。尽管该差异在统计学上不显着（p = 0.112），但已表明的趋势可能与临床相关，尤其是考虑到环丙沙星活性更高。环丙沙星治疗后凝固酶阴性葡萄球菌盖度（p = 0.004）和总细菌盖度（p = 0.019）下降了六倍，但诺氟沙星应用后出现的较小减少没有达到统计学意义（p> 0.1）。环丙沙星可减少外眼菌群，提示这可能是有用的术前预防剂。
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