Clinical safety tolerability pharmacokinetics and effects on urinary electrolyte excretion of AZD9977 a novel selective mineralocorticoid receptor modulator

摘要

AimsAZD9977 is the first mineralocorticoid receptor modulator in clinical development exerting similar organ protection as eplerenone with minimal urinary electrolyte effects in preclinical studies. The aim was to perform the initial clinical assessment of AZD9977.