Inhibition of oral midazolam clearance by boosting doses of ritonavir and by 44-dimethyl-benziso-(2H)-selenazine (ALT-2074) an experimental catalytic mimic of glutathione oxidase

摘要

AIMSWe evaluated whether ‘boosting’ doses of ritonavir can serve as a positive control inhibitor for pharmacokinetic drug–drug interaction studies involving cytochrome P450 3A (CYP3A). The study also determined whether 4,4-dimethyl-benziso-(2H)-selenazine (ALT-2074), an investigational organoselenium compound that acts as a catalytic mimic of glutathione oxidase, inhibits CYP3A metabolism in vivo.