Pharmacokinetics and pharmacodynamics of midazolam administered as a concentrated intranasal spray. A study in healthy volunteers

机译：咪达唑仑以浓鼻喷雾剂的药代动力学和药效学。健康志愿者研究

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摘要

AimsTo investigate the pharmacokinetic and pharmacodynamic profile of midazolam administered as a concentrated intranasal spray, compared with intravenous midazolam, in healthy adult subjects.

机译：目的探讨在健康成人受试者中与静脉给药咪达唑仑相比，以浓鼻内喷雾剂给药的咪达唑仑的药代动力学和药效学特征。

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期刊名称 British Journal of Clinical Pharmacology
作者
P D Knoester; D M Jonker; R T M van der Hoeven; T A C Vermeij; P M Edelbroek; G J Brekelmans; G J de Haan;
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作者单位

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年(卷),期 2002(53),5
年度 2002
页码 501–507
总页数 7
原文格式 PDF
正文语种
中图分类药学;
关键词
formulation intranasal intravenous midazolam modelling pharmacokinetics pharmacodynamics PK-PD;

机译：配方;鼻内;静脉内;咪达唑仑;模型;药代动力学;药效学;PK-PD;

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专利

1. Pharmacokinetics, pharmacodynamics, and safety of USL261, a midazolam formulation optimized for intranasal delivery, in a randomized study with healthy volunteers [J] . Bancke Lindy L., Dworak Heather A., Rodvold Keith A., Epilepsia: Journal of the International League against Epilepsy . 2015,第11期

机译：在一项针对健康志愿者的随机研究中，优化了鼻腔内给药的咪达唑仑制剂USL261的药代动力学，药效学和安全性
2. A pharmacokinetic and pharmacodynamic study, in healthy volunteers, of a rapidly absorbed intranasal midazolam formulation. [J] . Wermeling DP, Record KA, Archer SM, Epilepsy research . 2009,第2a3期

机译：在健康志愿者中进行快速吸收的鼻内咪达唑仑制剂的药代动力学和药效学研究。
3. Intranasal midazolam: Pharmacokinetics and pharmacodynamics assessed by quantitative EEG in healthy volunteers [J] . HardmeierM., ZimmermannR., RüeggS., Clinical Pharmacology and Therapeutics . 2012,第5期

机译：鼻内咪达唑仑：通过定量脑电图评估健康志愿者的药代动力学和药效学
4. Safety, tolerability, pharmacodynamics and pharmacokinetics following single subcutaneous dosesof a teverelix depot formulation in healthy male volunteers [C] . C. MacLean, F. Larsen, R. Piechatzek, Annual meeting exposition of the Controlled Release Society . 2005

机译：在健康男性志愿者中单次皮下注射Teverelix储库制剂后的安全性，耐受性，药效动力学和药代动力学
5. Propafenone pharmacokinetics: GLC-ECD analysis; metabolic induction by phenobarbital in nonsmoking and smoking healthy volunteers; protein binding; pharmacodynamics in patients [D] . Chan, Grace Lap-Yu 1989

机译：普罗帕酮药代动力学：GLC-ECD分析；非吸烟和吸烟健康志愿者的苯巴比妥诱导代谢；蛋白质结合；患者的药效学
6. Pharmacokinetics and Pharmacodynamics of Intranasal Insulin Spray (Nasulin™) Administered to Healthy Male Volunteers: [O] . Andrew C. Leary, Muiris Dowling, Kathleen Cussen, 2008

机译：健康男性志愿者鼻内胰岛素喷雾剂（Nasulin™）的药代动力学和药效学：
7. Pharmacokinetics and pharmacodynamics of midazolam administered as a concentrated intranasal spray. A study in healthy volunteers [O] . Knoester, P D, Jonker, D M, van der Hoeven, R T M, 2002

机译：咪达唑仑以浓鼻喷雾剂的药代动力学和药效学。健康志愿者研究

Pharmacokinetics and pharmacodynamics of midazolam administered as a concentrated intranasal spray. A study in healthy volunteers

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