An approach for dose finding of drugs in infants: sedation by midazolam studied using the continual reassessment method

摘要

AimsNo drug has been demonstrated to provide simultaneously appropriate sedation, safety and lack of disturbance of the measured parameters during cardiac catheterization in infants. The objective of this study was to estimate the dose of midazolam, administered rectally, that would provide a 90% probability of adequate sedation in infants during cardiac catheterization. A sedation score ≥4 (six-point scale) 30 to 60 min after dosing was rated as a success.