The effect of isoxicam-aspirin combinations on the polyurethane sponge implantation model in the rat

摘要

>1 Anti-inflammatory effects of isoxicam alone and in combination with aspirin were studied in rats using the polyurethane sponge implantation model of acute inflammation.>2 Dose-response studies were performed to delineate a suppressive (high) and non-suppressive (low) dose of isoxicam prior to studying these doses in combination with aspirin.>3 The results indicate that a combination of aspirin with isoxicam does not have an additive anti-inflammatory effect.>4 The interference demonstrated by aspirin with the anti-inflammatory effects of other NSAIDs such as indomethacin is also demonstrated with aspirin/isoxicam combinations.