1 Specific radioimmunoassays have been developed for the measurement of prednisolone and prednisone in serum. 2 Serum prednisolone levels have been measured following the administration of prednisone both with and without antacids. 3 There were no significant differences in the values of Cmax (mean +/- s.d.) (251 +/- 80 ng/ml with, 245 +/- 69 ng/ml without antacid), AUC (1430 +/- 469 ng ml-1 h-1 with, 1406 +/- 530 ng ml-1 h-1 without antacid) or Tmax (1.6 +/- 0.6 h with, 1.6 +/- 0.8 h without antacid). 4 Serum prednisone levels were less than 20% of prednisolone levels at all time intervals in the subjects studied. 5 Concurrent antacid administration has no significant effect on serum prednisolone levels attained.
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机译：1已经开发了用于测定血清中泼尼松龙和泼尼松的特异性放射免疫分析方法。 2泼尼松联合使用和不联合使用抗酸剂后，均已测定了血清泼尼松龙的水平。 3 Cmax（平均值+/- sd）（使用抗酸剂时为251 +/- 80 ng / ml，不使用抗酸剂时为245 +/- 69 ng / ml），AUC（1430 +/- 469 ng ml）的值无显着差异-1 h-1（含抗酸剂1406 +/- 530 ng ml-1 h-1）或Tmax（含抗酸剂1.6 +/- 0.6 h，不含抗酸剂1.6 +/- 0.8 h）。 4在所有时间间隔内，受试者的血清泼尼松水平均低于泼尼松龙水平的20％。 5同时服用抗酸药对获得的血清泼尼松龙水平没有明显影响。
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