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Poliomyelitis: epidemiology and prophylaxis

机译:脊髓灰质炎:流行病学和预防

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摘要

In 1973, a type 1 poliomyelitis epidemic in Kenya was curtailed at an early stage by two mass distributions of trivalent oral vaccine. It was considered useful to know the immunity status of the child population that had resulted from the vaccine distributions and that had presumably contributed to its control. We also wished to know to what extent wild and vaccine virus strains were in circulation after the mass vaccination campaign. Anal swabs and blood were collected from a sample of the children in four areas where the efficiency of vaccine distribution had varied, and the results of virus isolation attempts and antibody tests are reported. Three poliovirus strains were isolated. It was surprising that, in general, the herd immunity after two vaccination rounds did not substantially differ from that found in Kenya on other occasions. Possible reasons for these results are discussed.
机译:1973年,肯尼亚的1型脊髓灰质炎流行在早期通过两种三价口服疫苗的大规模分发而得到遏制。了解由疫苗的分布所致的儿童人群的免疫状况被认为是有用的,并且大概有助于控制其免疫。我们还希望知道大规模疫苗接种运动之后野生和疫苗病毒株在何种程度上流通。从四个地区的儿童样本中收集了肛门拭子和血液,这些地区的疫苗分发效率有所不同,并且报告了病毒分离尝试和抗体测试的结果。分离出三种脊髓灰质炎病毒株。令人惊讶的是,总体而言,两轮疫苗接种后的牛群免疫力与肯尼亚在其他场合的免疫力没有实质性差异。讨论了导致这些结果的可能原因。

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