Dose escalation improves therapeutic outcome: post hoc analysis of data from a 12-week multicentre double-blind parallel-group trial of trospium chloride in patients with urinary urge incontinence

摘要

BackgroundFlexible dosing of anticholinergics used for overactive bladder (OAB) treatment is a useful strategy in clinical practice for achieving a maximum effective and maximum tolerated level of therapeutic benefit. In this post hoc analysis we evaluated the efficacy and tolerability of trospium chloride treatment for urinary urge incontinence (UUI) with focus on flexible dosing.