Successful Recanalization of Thrombotic Occlusion in Pulmonary Artery Stent Using Sonothrombolysis

摘要

class="kwd-title">Keywords: Pulmonary embolism, Sonothrombolysis, Microbubbles class="head no_bottom_margin" id="sec1title">IntroductionRecently, it has been shown that intermittent high–mechanical index impulses from a diagnostic transthoracic ultrasound system can recanalize acutely thrombosed vessels in animal models of arteriovenous graft thrombosis and acute myocardial infarction during an intravenous infusion of ultrasound contrast agent., The safety and success of this technique in large animal models have led to the first clinical investigation of this technique in acute ST-segment elevation myocardial infarction, which is ongoing at our institution. This has demonstrated that diagnostic high–mechanical index impulses applied transthoracically before invasive angiography increased the early recanalization rate of the culprit coronary artery to nearly 60% before percutaneous intervention. Although intravascular ultrasound catheters have been used for pulmonary artery thrombi, there is no published report regarding the use of intravenous microbubbles and transthoracic ultrasound for the treatment of pulmonary embolism.