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Facial Involuntary Movements and Respiratory Failure in CANOMAD Responsive to IVIG Therapy

机译:CANOMAD中的面部非自愿运动和呼吸衰竭对IVIG治疗有反应

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摘要

CANOMAD is a rare chronic neuropathy, characterized by chronic sensory ataxia and intermittent brain stem symptoms due to antidisialosyl antibodies. The disorder results in significant morbidity but is poorly understood and often misdiagnosed. We describe a unique case of CANOMAD, associated with involuntary movements of the face; patient reported exacerbations with citrus and chocolate and respiratory muscle weakness. Our patient was initially misdiagnosed with Miller Fisher Syndrome, highlighting the need for vigilance should neurological symptoms recur in patients initially diagnosed with a Guillain Barre variant. Moreover, the optimal treatment is unknown. This patient responded remarkably to intravenous immunoglobulin and has been maintained on this treatment, without further exacerbations.
机译:CANOMAD是一种罕见的慢性神经病,其特征是由于抗二唾液酸抗体引起的慢性感觉共济失调和间歇性脑干症状。该疾病导致明显的发病率,但知之甚少并且经常被误诊。我们描述了CANOMAD的一种独特情况,与面部的不自主运动有关;该患者报告了柑橘和巧克力加重以及呼吸肌无力的发作。我们的患者最初被误诊为米勒·费雪综合症,强调了在最初诊断为吉兰·巴雷变种的患者中出现神经系统症状时应保持警惕。而且,最佳治疗方法还未知。该患者对静脉内免疫球蛋白有显着反应,并一直维持这种治疗,而无进一步恶化。

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