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Hidden under a Cauliflower-Like Skin Tumor: Chromoblastomycosis

机译:隐藏在花椰菜样皮肤肿瘤下:色母细胞病

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摘要

We present the case of an 80-year-old patient with a recurrent hyperpigmented and cauliflower-like skin tumor on the stump of his left index finger. Despite suggestive clinical appearance for chromoblastomycosis the tumor was initially clinically and also histopathologically misdiagnosed as recurrent squamous cell carcinoma. Due to a cardiogenic shock, the patient died shortly after the diagnosis of chromoblastomycosis, before adequate treatment could be introduced. In non-tropical regions chromoblastomycosis is an uncommon chronic fungal infection with Fonsecaea pedrosoi being the most prevalent etiological agent. Mostly lower extremities are involved. It is not unusual that, clinically, in the absence of pigmentation, and, histopathologically, because of pseudoepitheliomatous hyperplasia of the epidermis, chromoblastomycosis is confounded with squamous cell cancer, and delays in diagnosis of one to 3 years are common. Therefore, a high grade of clinical suspicion and inclusion of chromoblastomycosis in the differential diagnosis of pigmented skin tumors are important to initiate adequate therapy. Our case is remarkable in many aspects. The localization on an upper extremity and the grade of invasiveness with involvement of bone are unusual; furthermore the lack of a tropical travel history emphasizes that the infection almost surely occurred in Switzerland.
机译:我们介绍了一个80岁患者的左食指残端复发性色素沉着和花椰菜样皮肤肿瘤的病例。尽管有明显的色母细胞增多症临床表现,但该肿瘤最初在临床上以及在组织病理学上被误诊为复发性鳞状细胞癌。由于心源性休克,该患者在诊断为成色母细胞病后不久就死亡,之后才可以采取适当的治疗措施。在非热带地区,成色菌病是一种罕见的慢性真菌感染,其中以凤尾草为最普遍的病原体。通常涉及下肢。在临床上,在没有色素沉着的情况下,并且在组织病理学上,由于表皮的假上皮性增生,将成色细胞病与鳞状细胞癌相混淆是很常见的,并且诊断延迟一到三年是很常见的。因此,在色斑皮肤肿瘤的鉴别诊断中,高度的临床怀疑和色母细胞病的包容对于启动适当的治疗很重要。我们的案例在许多方面都非常出色。上肢的定位和骨累及的浸润程度是不寻常的;此外,由于缺乏热带旅行史,这说明感染几乎肯定发生在瑞士。

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