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Cisplatin-Induced Eosinophilic Pneumonia

机译:顺铂诱导的嗜酸性肺炎

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摘要

A 67-year-old man suffering from esophageal cancer was admitted to our hospital complaining of dyspnea and hypoxemia. He had been treated with cisplatin, docetaxel, and fluorouracil combined with radiotherapy. Chest computed tomography revealed bilateral ground-glass opacity, and bronchoalveolar lavage fluid showed increased eosinophils. Two episodes of transient eosinophilia in peripheral blood were observed after serial administration of anticancer drugs before the admission, and drug-induced lymphocyte stimulation test to cisplatin was positive. Thus cisplatin-induced eosinophilic pneumonia was suspected, and corticosteroid was effectively administered. To our knowledge, this is the first reported case of cisplatin-induced eosinophilic pneumonia.
机译:一名患有食道癌的67岁男子因呼吸困难和低氧血症入院。他曾接受顺铂,多西他赛和氟尿嘧啶联合放疗的治疗。胸部计算机断层扫描显示双侧毛玻璃样混浊,支气管肺泡灌洗液显示嗜酸性粒细胞增多。入院前连续服用抗癌药后观察到两次外周血短暂性嗜酸性粒细胞增多,药物对顺铂的淋巴细胞刺激试验阳性。因此,怀疑是顺铂诱导的嗜酸性粒细胞性肺炎,并且有效地使用了皮质类固醇。据我们所知,这是首例顺铂诱导的嗜酸性粒细胞性肺炎报道。

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