Chlorpyrifos Toxicity in Mouse Cultured Cerebellar GranuleNeurons at Different Stages of Development: AdditiveEffect on Glutamate-Induced Excitotoxicity

摘要

Objective Chlorpyrifos (CPF) is a neurotoxic organophosphorus (OP) insecticide. Its mechanism of action includes oxidative stress, excitotoxicity, and inhibition of the acetylcholinesterase enzyme (AChE). The aim of the present study is to investigate CPF toxicity in mature and immature cerebellar granule neurons (CGNs), as well as its effect on glutamate induced excitotoxicity.