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Metabotropic glutamate receptor 5 tracer 18F-FPEB displays increased binding potential in postcentral gyrus and cerebellum of male individuals with autism: a pilot PET study

机译：代谢性谷氨酸受体5示踪剂18F -FPEB在患有孤独症的男性个体的中央后回和小脑中显示出增加的结合潜力

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BackgroundAutism is a neurodevelopmental disorder that is first manifested during early childhood. Postmortem experiments have identified significantly elevated expression of metabotropic glutamate receptor 5 (mGluR5) in cerebellar vermis and prefrontal cortex of individuals with autism.

机译：背景自闭症是一种神经发育障碍，最初在儿童早期就表现出来。验尸实验已经发现自闭症患者小脑ver和前额叶皮层中代谢型谷氨酸受体5（mGluR5）的表达明显升高。

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期刊名称 Cerebellum Ataxias
作者
S. Hossein Fatemi; Dean F. Wong; James R. Brašić; Hiroto Kuwabara; Anil Mathur; Timothy D. Folsom; Suma Jacob; George M. Realmuto; José V. Pardo; Susanne Lee;
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年(卷),期 2018(5),-1
年度 2018
页码 3
总页数 8
原文格式 PDF
正文语种
中图分类神经科学;
关键词
PET Autism mGluR5 Cerebellum Postcentral gyrus Precuneus sup18/supF-3-fluoro-5-(pyridin-3-yl)ethynylbenzonitrile;

机译：PET;自闭症;mGluR5;小脑;中央后回;早产儿;sup 18 / sup F -3-氟-5-（吡啶-3-基）乙炔基苄腈;

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1. Metabotropic glutamate receptor 5 tracer [ 18 F]-FPEB displays increased binding potential in postcentral gyrus and cerebellum of male individuals with autism: a pilot PET study [J] . S. Hossein Fatemi, Dean F. Wong, James R. Bra?i?, Cerebellum & Ataxias . 2018,第1期

机译：代谢性谷氨酸受体5示踪剂[18 F] -FPEB在患有自闭症的男性个体的中央后回和小脑中显示出增加的结合潜力
2. 18F-FPEB, a PET radiopharmaceutical for quantifying metabotropic glutamate 5 receptors: A first-in-human study of radiochemical safety, biokinetics, and radiation dosimetry [J] . WongD.F., WaterhouseR., KuwabaraH., The Journal of Nuclear Medicine . 2013,第3期

机译：18F-FPEB，一种用于量化代谢型谷氨酸5受体的PET放射性药物：放射化学安全性，生物动力学和辐射剂量学的首次人类研究
3. 18F-FPEB, a PET Radiopharmaceutical for Quantifying Metabotropic Glutamate 5 Receptors: A First-in-Human Study of Radiochemical Safety, Biokinetics, and Radiation Dosimetry [J] . Daniel P. Holt, Dean F. Wong, Hiroto Kuwabara, The Journal of Nuclear Medicine . 2013,第3期

机译：18F-FPEB，一种用于量化代谢型谷氨酸5受体的PET放射性药物：放射化学安全性，生物动力学和辐射剂量学的首次人体研究
4. Enhanced Binding of Metabotropic Glutamate Receptor Type 5 (mGluR5) PET Tracers in the Brain of Parkinsonian Primates [O] . R Sanchez-Pernaute, J-Q Wang, D Kuruppu, -1

机译：帕金森氏灵长类动物脑中5型代谢型谷氨酸受体（mGluR5）PET示踪剂的增强结合。
5. Metabotropic glutamate receptor 3 neuroprotection A. Berent-Spillson and J. W. Russell Received June 12, 2006; revised manuscript received October 3, 2006; accepted October 5, 2006. Address correspondence and reprint requests to James W. Russell, Department of Neurology, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201-1595, USA. E-mail: jruss@umich.edu Abbreviations used : APDC , 2 R ,4 R -4-aminopyrrolidine-2,4-dicarboxylate (specific metabotropic glutamate receptor 3 agonist) ; BSO , buthionine sulfoximine (GSH synthesis inhibitor) ; caspase , cysteine-requiring aspartate protease ; CysGly , cysteinylglycine (GSH degradation product) ; DAPI , 4′-6-diamidino-2-phenylindole ; DCF , dichlorodihydrofluorescein ; DCFDA , 5-(and 6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate, acetyl ester ; DHE , dihydroethidium ; DRG , dorsal root ganglion ; FCCP , carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (electron transport uncoupler) ; GCP II/III , glutamate carboxypeptidase II/III ; GSH , glutathione ; GSH-EE , glutathione ethyl ester ; GST , glutathione-s-transferase ; H 2 O 2 , hydrogen peroxide ; HBSS , Hank’s balanced salt solution ; JC-1 , 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide ; MCB , monochlorobimane ; mGluR , metabotropic glutamate receptor ; NAAG , N -acetyl-aspartyl-glutamate ; PBS , phosphate-buffered saline ; PCD , programmed cell death ; Rh123 , rhodamine123 ; ROS , reactive oxygen species ; δψ μ , inner mitochondrial membrane potential . Metabotropic glutamate receptor 3 protects neurons from glucose-induced oxidative injury by increasing intracellular glutathione concentration [O] . Berent-Spillson Alison, Russell James W. 2007

机译：代谢型谷氨酸受体3神经保护a. Berent-spillson和J. W. Russell于2006年6月12日收到;修订稿于2006年10月3日收到; 2006年10月5日接受。美国马里兰州巴尔的摩市南格林街22号，马里兰大学医学院神经病学系James W. Russell的地址通信和重印申请。电子邮件：jruss@umich.edu使用的缩写：apDC，2R，4R-4-氨基吡咯烷-2,4-二羧酸酯（特异性代谢型谷氨酸受体3激动剂）; BsO，丁硫氨酸亚砜亚胺（GsH合成抑制剂）;半胱天冬酶，半胱氨酸需要的天冬氨酸蛋白酶; CysGly，半胱氨酰甘氨酸（GsH降解产物）; DapI，4'-6-二脒基-2-苯基吲哚; DCF，二氯二氢荧光素; DCFDa，5-（和6） - 氯甲基-2'，7'-二氯二氢荧光素二乙酸酯，乙酰酯; DHE，二氢乙锭; DRG，背根神经节; FCCp，羰基氰化物4-（三氟甲氧基）苯腙（电子传输解偶联剂）; GCp II / III，谷氨酸羧肽酶II / III;谷胱甘肽;谷胱甘肽; GsH-EE，谷胱甘肽乙酯; GsT，谷胱甘肽-s-转移酶; H 2 O 2，过氧化氢; HBss，Hank的平衡盐溶液; JC-1,5,5'，6,6'-四氯-1,1'，3,3'-四乙基苯并咪唑基酞菁碘化物; mCB，monochlorobimane; mGluR，代谢型谷氨酸受体; NaaG，N-乙酰基 - 天冬氨酰谷氨酸; pBs，磷酸盐缓冲盐水; pCD，程序性细胞死亡; Rh123，罗丹明123;活性氧，活性氧; δψμ，线粒体内膜电位。代谢型谷氨酸受体3通过增加细胞内谷胱甘肽浓度来保护神经元免受葡萄糖诱导的氧化损伤

Metabotropic glutamate receptor 5 tracer 18F-FPEB displays increased binding potential in postcentral gyrus and cerebellum of male individuals with autism: a pilot PET study

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