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Effects of selective neutrality on the evolution of molecular species

机译:选择性中性对分子物种进化的影响

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摘要

We introduce a model of evolution on a fitness landscape possessing a tunable degree of neutrality. The model allows us to study the general properties of molecular species undergoing neutral evolution. We find that a number of phenomena seen in RNA sequence-structure maps are present also in our general model. Examples are the occurrence of 'common' structures that occupy a fraction of the genotype space which tends to unity as the length of the genotype increases, and the formation of percolating neutral networks that cover the genotype space in such a way that a member of such a network can be found within a small radius of any point in the space. We also describe a number of new phenomena that appear to be general properties of systems possessing selective neutrality. In particular, we show that the maximum fitness attained during the adaptive walk of a population evolving on such a fitness landscape increases with increasing degree of neutrality, and is directly related to the fitness of the most fit percolating network.
机译:我们在具有可调整的中性程度的健身环境中引入了一种进化模型。该模型使我们能够研究经历中性进化的分子种类的一般性质。我们发现在我们的一般模型中也存在在RNA序列结构图中看到的许多现象。例如,“共同”结构的出现占据了基因型空间的一小部分,该基因型空间随着基因型长度的增加而趋于统一,并且形成了覆盖基因型空间的渗滤性中性网络,使得这种成员在空间中任何点的小半径范围内都可以找到一个网络。我们还描述了许多新现象,这些新现象似乎是具有选择中立性的系统的一般属性。尤其是,我们表明,在这种适应性景观上进化的人群的自适应步行过程中,获得的最大适应性随着中性程度的提高而增加,并且与最适合的渗滤网络的适应性直接相关。

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