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MicroRNA profiling of ovarian granulosa cell tumours reveals novel diagnostic and prognostic markers

机译：卵巢颗粒细胞瘤的MicroRNA分析揭示了新的诊断和预后标志物

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摘要

BackgroundThe aim of this study was to explore the clinical utility of microRNAs (miRNAs) as improved markers of ovarian granulosa cell tumours (GCTs) for cancer diagnosis and prognosis prediction. Current histopathological and genetic markers, such as the presence of a FOXL2 gene mutation to distinguish between the two major subtypes are not wholly accurate and as such novel biomarkers are warranted.

机译：背景技术这项研究的目的是探索microRNA（miRNA）作为卵巢颗粒细胞肿瘤（GCT）的改良标记物在癌症诊断和预后预测中的临床应用。当前的组织病理学和遗传标记，例如是否存在区分两个主要亚型的FOXL2基因突变，并不完全准确，因此有必要使用这种新颖的生物标记。

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期刊名称 Clinical Epigenetics
作者
Wei-Tzu Cheng; Roseanne Rosario; Anita Muthukaruppan; Michelle K Wilson; Kathryn Payne; Peter C. Fong; Andrew N. Shelling; Cherie Blenkiron;
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作者单位

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年(卷),期 2017(9),-1
年度 2017
页码 72
总页数 10
原文格式 PDF
正文语种
中图分类遗传学;
关键词
Tissue biomarker Prognosticator Ovarian cancer Granulosa cell Non-coding RNA;

机译：组织生物标志物;预后因子;卵巢癌;颗粒细胞;非编码RNA;
入库时间 2022-08-17 13:07:35

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专利

1. Practical roles for molecular diagnostic testing in ovarian adult granulosa cell tumour, Sertoli–Leydig cell tumour, microcystic stromal tumour and their mimics [J] . Rabban Joseph T, Karnezis Anthony N, Devine W Patrick Histopathology: Official Journal of the British Division of the International Academy of Pathology . 2020,第1期

机译：卵巢成年颗粒细胞瘤中分子诊断检测的实用作用，Sertoli-Leydig细胞肿瘤，微肾间基质肿瘤及其模拟物
2. MicroRNA-184 acts as a potential diagnostic and prognostic marker in epithelial ovarian cancer and regulates cell proliferation, apoptosis and inflammation [J] . Qin Chong-Zhen, Lou Xiao-Ya, Lv Qiao-Li, Die Pharmazie . 2015,第10期

机译：MicroRNA-184可作为上皮性卵巢癌的潜在诊断和预后标志物，并调节细胞增殖，凋亡和炎症
3. Tumour-suppressive microRNA-424-5p directly targets CCNE1 as potential prognostic markers in epithelial ovarian cancer [J] . Liu Jingjing, Gu Zhenpeng, Tang Yujie, Cell cycle . 2018,第3期

机译：肿瘤抑制microRNA-424-5P直接靶向CCNE1作为上皮性卵巢癌中的潜在预后标志物
4. Regulatory Mechanisms of granulosa cell apoptosis in ovarian follicle atresia: Role of Granulosa Cell Apoptosis in Porcine Ovarian Follicle Atresia [C] . N.MANABE, Y. KIMURAauthor_name/, H. MATSUSHITA, Joint International Meeting of the Japanese Association for Animal Cell Technolog and and European Society for Animal Cell Technology . 1999

机译：卵巢卵巢腺炎粒细胞凋亡的调节机制：甘蓝粒细胞凋亡在猪卵巢卵巢毛囊炎中的作用
5. MicroRNA expression within periovulatory mural granulosa cells. [D] . Fiedler, Stephanie D. 2008

机译：围排卵期壁颗粒细胞内的MicroRNA表达。
6. Diagnostic relevance of urinary steroid profiles on ovarian granulosa cell tumors: two case reports [O] . Anita Bufa, Nelli Farkas, Zsolt Preisz, 2017

机译：尿类固醇激素谱对卵巢颗粒细胞瘤的诊断意义：两例
7. MicroRNA profiling of ovarian granulosa cell tumours reveals novel diagnostic and prognostic markers [O] . Wei-Tzu Cheng, Roseanne Rosario, Anita Muthukaruppan, 2017

机译：卵巢颗粒细胞瘤的MicroRNA分析揭示了新型诊断和预后标志物

MicroRNA profiling of ovarian granulosa cell tumours reveals novel diagnostic and prognostic markers

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