首页> 美国卫生研究院文献>Clinical and Experimental Immunology >Coincidence of different structures of mucosa-associated lymphoid tissue (MALT) in the respiratory tract of children: no indications for enhanced mucosal immunostimulation in sudden infant death syndrome (SIDS)
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Coincidence of different structures of mucosa-associated lymphoid tissue (MALT) in the respiratory tract of children: no indications for enhanced mucosal immunostimulation in sudden infant death syndrome (SIDS)

机译:儿童呼吸道粘膜相关淋巴样组织(MALT)不同结构的巧合:没有迹象表明婴儿猝死综合征(SIDS)的粘膜免疫刺激作用增强

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摘要

Mucosa-associated lymphoid tissue (MALT) is the principal inductive site for mucosal immune responses that are capable of T and B cell responses and antigen-specific responses. In previous independent studies different structures of MALT, e.g. bronchus-, larynx- and nose-associated lymphoid tissue (BALT, LALT, NALT) have been described separately in various frequencies in the human respiratory tract over life spans. Because upper respiratory tract infections are common in infants, dysregulations of mucosal immune responses might be seriously involved in the aetiology of sudden infant death syndrome (SIDS). In the present study the coincidental occurrence of the three different MALT structures in the respiratory tract within the same patients were studied, and cases of SIDS and children who had died from different traumatic and natural causes of death (non-SIDS) were compared. First, the frequency of BALT and LALT in 46 children (35 SIDS, 11 non-SIDS) with or without NALT were examined. A tendency was found of a coincidence of respiratory MALT structures. In 50 additional cases of infant death (30 SIDS, 20 non-SIDS) from the multi-centric German Study on Sudden Infant Death Syndrome (GeSID) where death had occurred in the first year of life, the coincidence was evaluated. A coincidental occurrence of BALT, LALT and NALT or BALT and LALT (each about 30%) was found in both groups, whereby the coincidence in SIDS and the control patients did not differ. Interestingly, the children with coincidental MALT were strikingly older, supporting the hypothesis of respiratory MALT formation via environmental stimulation over time.
机译:粘膜相关淋巴组织(MALT)是粘膜免疫反应的主要诱导位点,能够进行T细胞和B细胞反应以及抗原特异性反应。在先前的独立研究中,MALT的不同结构例如在整个生命周期中,已经以各种频率分别描述了支气管,喉和鼻子相关的淋巴样组织(BALT,LALT,NALT)。由于上呼吸道感染在婴儿中很常见,因此粘膜免疫反应异常可能与婴儿猝死综合症(SIDS)的病因密切相关。在本研究中,研究了同一患者中呼吸道中三种不同MALT结构的同时发生,并比较了SIDS病例和因不同外伤和自然死亡原因(非SIDS)死亡的儿童。首先,检查了有或没有NALT的46名儿童(35名SIDS,11名非SIDS)的BALT和LALT频率。发现呼吸MALT结构重合的趋势。来自德国多中心婴儿猝死综合症研究(GeSID)的另外50例婴儿死亡(30例SIDS,20例非SIDS)中,死亡发生在生命的第一年。两组均同时发生BALT,LALT和NALT或BALT和LALT(各占30%),因此SIDS与对照组患者的符合率没有差异。有趣的是,患有巧合MALT的儿童年龄大得惊人,支持了随着时间的推移通过环境刺激而形成呼吸道MALT的假说。

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