首页> 美国卫生研究院文献>Clinical and Experimental Immunology >Antibody-dependent cellular cytotoxicity (ADCC) against Epstein-Barr virus-determined membrane antigens. I. Reactivity in sera from normal persons and from patients with acute infectious mononucleosis.
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Antibody-dependent cellular cytotoxicity (ADCC) against Epstein-Barr virus-determined membrane antigens. I. Reactivity in sera from normal persons and from patients with acute infectious mononucleosis.

机译:针对爱泼斯坦-巴尔病毒确定的膜抗原的抗体依赖性细胞毒性(ADCC)。 I.正常人和急性传染性单核细胞增多症患者的血清反应性。

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摘要

The capacity of antibodies, directed against EBV-determined membrane antigens (MA), to induce antibody-dependent cellular cytotoxicity (ADCC) against EBV superinfected lymphoid cell lines was investigated. Such reactive antibodies were found, at high dilutions, in sera from normal EBV-positive persons but not in sera from EBV-negative persons. Sera from patients with acute infectious mononucleosis (IM), which develop EBV-specific killer T cells, did not induce ADCC. The difference in specificity between ADCC and EBV-specific killer T cells is briefly discussed.
机译:研究了针对EBV决定的膜抗原(MA)的抗体诱导针对EBV感染的淋巴样细胞系的抗体依赖性细胞毒性(ADCC)的能力。在高稀释度下,在正常EBV阳性人的血清中发现了这种反应性抗体,而在EBV阴性人的血清中未发现。患有EBV特异性杀伤性T细胞的急性感染性单核细胞增多症(IM)患者的血清未诱导ADCC。简要讨论了ADCC和EBV特异性杀伤性T细胞之间的特异性差异。

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