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Clinical implementation of rapid CYP2C19 genotyping to guide antiplatelet therapy after percutaneous coronary intervention

机译：CYP2C19快速基因分型指导经皮冠状动脉介入治疗后抗血小板治疗的临床实施

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BackgroundThe CYP2C19 nonfunctional genotype reduces clopidogrel effectiveness after percutaneous coronary intervention (PCI). Following clinical implementation of CYP2C19 genotyping at University Florida (UF) Health Shands Hospital in 2012, where genotype results are available approximately 3 days after PCI, testing was expanded to UF Health Jacksonville in 2016 utilizing a rapid genotyping approach. We describe metrics with this latter implementation.

机译：背景CYP2C19非功能基因型会降低经皮冠状动脉介入治疗（PCI）后的氯吡格雷有效性。 CYP2C19基因分型于2012年在佛罗里达大学（UF）Health Shands医院临床实施后，在PCI后约3天可获得基因型结果，2016年通过快速基因分型方法将检测扩展到UF Health Jacksonville。我们在后一种实现中描述指标。

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期刊名称 Journal of Translational Medicine
作者
Larisa H. Cavallari; Francesco Franchi; Fabiana Rollini; Latonya Been; Andrea Rivas; Malhar Agarwal; D. Max Smith; Kimberly Newsom; Yan Gong; Amanda R. Elsey; Petr Starostik; Julie A. Johnson; Dominick J. Angiolillo;
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作者单位

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年(卷),期 2018(16),-1
年度 2018
页码 92
总页数 10
原文格式 PDF
正文语种
中图分类医学史;
关键词
CYP2C19 Genotype Clopidogrel Percutaneous coronary intervention Ticagrelor Prasugrel;

机译：CYP2C19;基因型;氯吡格雷;经皮冠状动脉介入治疗;替卡格雷;普拉格雷;

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专利

1. Clinical implementation of rapid CYP2C19 genotyping to guide antiplatelet therapy after percutaneous coronary intervention [J] . Larisa H. Cavallari, Francesco Franchi, Fabiana Rollini, Journal of Translational Medicine . 2018,第1期

机译：CYP2C19快速基因分型在经皮冠状动脉介入治疗后指导抗血小板治疗的临床实施
2. Multisite Investigation of Outcomes With?Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention [J] . Larisa H. Cavallari, Craig R. Lee, Amber L. Beitelshees, JACC. Cardiovascular interventions . 2018,第2期

机译：多能调查结果与CYP2C19基因型引导抗血小板治疗经皮冠状动脉干预后的实施
3. Clinical Utility of CYP2C19 Genotyping to Guide Antiplatelet Therapy in Patients With an Acute Coronary Syndrome or Undergoing Percutaneous Coronary Intervention [J] . Klein Melissa D., Williams Alexis K., Lee Craig R., Arteriosclerosis, thrombosis, and vascular biology . 2019,第4期

机译：CYP2C19基因分型对急性冠状动脉综合征或经皮冠状动脉介入患者抗血小板治疗的临床效用
4. Evaluation of clinical outcomes using exercise test in patients with coronary artery disease after percutaneous coronary intervention [C] . Mintale Iveta, Zabunova Milana, Lurina Dace, International Congress on Coronary Artery Disease . 2009

机译：经皮冠状动脉介入后冠状动脉疾病患者运动试验评估临床结果
5. The Association between Unfractionated Heparin and Bivalirudin Used during Percutaneous Coronary Intervention for Stable Angina and Acute Coronary Syndromes and the In-Hospital and Mortality Outcomes Observed across All Body Mass Index Groups [D] . Chen, Christine. 2021

机译：在所有体重指数群体中观察到稳定冠状动脉干预期间使用经皮冠状动脉介入和急性冠状动脉综合征的冠状动脉介入和医院和死亡率结果之间的联合肝素和Bivalirudin之间的关联
6. Impact of Implementing CYP2C19 Genotype-Guided Antiplatelet Therapy on P2Y12 Inhibitor Selection and Clinical Outcomes in Acute Coronary Syndrome Patients After Percutaneous Coronary Intervention: A Real-World Study in China [O] . Yi Zhang, Xiu-Jin Shi, Wen-Xing Peng, 2020

机译：经皮冠状动脉干预后实施CYP2C19基因型引导抗血小板治疗抗血小板治疗对急性冠状动脉综合征患者P2Y12抑制剂选择及临床结果的影响：中国的真实研究
7. Correction to: Influence of CYP2C19 genotypes for the effect of 1‑month dual antiplatelet therapy followed by clopidogrel monotherapy relative to 12‑month dual antiplatelet therapy on clinical outcomes after percutaneous coronary intervention: a genetic substudy from the STOPDAPT‑2 [O] . Hirotoshi Watanabe, Takeshi Morimoto, Manabu Ogita, 2021

机译：校正：CYP2C19基因型对1个月双抗血小板治疗的影响，氯吡格雷单疗法相对于经皮冠状动脉干预后12个月的双抗血小板治疗临床结果：Stopdapt-2的遗传算法

Clinical implementation of rapid CYP2C19 genotyping to guide antiplatelet therapy after percutaneous coronary intervention

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