Effect of γ-secretase inhibitor on Th17 cell differentiation and function of mouse psoriasis-like skin inflammation

机译：γ-分泌酶抑制剂对小鼠牛皮癣样皮肤炎症Th17细胞分化和功能的影响

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BackgroundTh17 cells and its effective cytokine IL-17A play an important role in the pathogenesis of abnormal immune responses in psoriasis. Notch1 signaling has been implicated in Th17 cell differentiation and function. In this study, our aim was to evaluate the possible inhibitory effect of Notch1 signaling inhibitor, γ-secretase inhibitor DAPT, on psoriatic Th17 cell differentiation and function in a mouse model of psoriasis-like skin inflammation.

机译：背景Th17细胞及其有效的细胞因子IL-17A在牛皮癣异常免疫反应的发病机理中起着重要作用。 Notch1信号传导与Th17细胞的分化和功能有关。在这项研究中，我们的目的是评估在牛皮癣样皮肤炎症的小鼠模型中，Notch1信号抑制剂，γ-分泌酶抑制剂DAPT对银屑病Th17细胞分化和功能的可能抑制作用。

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期刊名称 Journal of Translational Medicine
作者
Lei Ma; Haibo Xue; Ruiqun Qi; Yanqin Wang; Libing Yuan;
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作者单位

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年(卷),期 2018(16),-1
年度 2018
页码 59
总页数 10
原文格式 PDF
正文语种
中图分类医学史;
关键词
Psoriasis Notch1 signaling Th17 cells γ-secretase inhibitor;

机译：牛皮癣;Notch1信号传导;Th17细胞;γ-分泌酶抑制剂;

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专利

1. Effect of γ-secretase inhibitor on Th17 cell differentiation and function of mouse psoriasis-like skin inflammation [J] . Lei Ma, Haibo Xue, Ruiqun Qi, Journal of Translational Medicine . 2018,第1期

机译：γ-分泌酶抑制剂对小鼠牛皮癣样皮肤炎症Th17细胞分化和功能的影响
2. Astilbin inhibits Th17 cell differentiation and ameliorates imiquimod-induced psoriasis-like skin lesions in BALB/c mice via Jak3/Stat3 signaling pathway [J] . Di Ting-Ting, Ruan Zhi-Tong, Zhao Jing-Xia, International immunopharmacology . 2016,第Null期

机译：曲霉菌素通过Jak3 / Stat3信号通路抑制BALB / c小鼠Th17细胞分化并改善咪喹莫特诱导的牛皮癣样皮肤损伤
3. γ-Secretase Inhibitor Alleviates Acute Airway Inflammation of Allergic Asthma in Mice by Downregulating Th17 Cell Differentiation [J] . WeixiZhang, XueyaZhang, AnqunSheng, Mediators of inflammation . 2015,第6期

机译：γ-分泌酶抑制剂通过下调Th17细胞分化减轻小鼠过敏性哮喘的急性气道炎症
4. Analysis of dynamics of Th17 cells in chronic middle ear inflammation induced by nontypeable Haemophilus influenzae [C] . Hirano T., Kodama S., Kawano T., Extraordinary International Symposium on Recent Advances in Otitis Media . 2014

机译：嗜血杆菌诱导慢性中耳炎症Th17细胞动力学分析
5. Selective CB2 receptor activation ameliorates inflammation in central nervous system by reducing Th17 cell differentiation and immune cell accumulation. [D] . Li, Hongbo. 2014

机译：选择性的CB2受体激活通过减少Th17细胞分化和免疫细胞积累来改善中枢神经系统的炎症。
6. IL-22 is required for Th17 cell–mediated pathology in a mouse model of psoriasis-like skin inflammation [O] . Hak-Ling Ma, Spencer Liang, Jing Li, 2008

机译：在银屑病样皮肤炎症的小鼠模型中Th22细胞介导的病理学需要IL-22
7. Effect of γ-secretase inhibitor on Th17 cell differentiation and function of mouse psoriasis-like skin inflammation [O] . Lei Ma, Haibo Xue, Ruiqun Qi, 2018

机译：γ分泌酶抑制剂对小鼠牛皮癣皮肤炎症Th17细胞分化和功能的影响

Effect of γ-secretase inhibitor on Th17 cell differentiation and function of mouse psoriasis-like skin inflammation

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