The adenosine deaminase inhibitor erythro-9-2-hydroxyl-3-nonyl-adenine decreases intestinal permeability and protects against experimental sepsis: a prospective randomised laboratory investigation

摘要

IntroductionThe treatment of septic conditions in critically ill patients is still one of medicine's major challenges. Cyclic nucleotides, adenosine and its receptors play a pivotal role in the regulation of inflammatory responses and in limiting inflammatory tissue destruction. The aim of this study was to verify the hypothesis that adenosine deaminase-1 and cyclic guanosine monophosphate-stimulated phosphodiesterase inhibition by erythro-9-[2-hydroxyl-3-nonyl]-adenine could be beneficial in experimental endotoxicosis/sepsis.