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Device Therapies: New Indications and Future Directions

机译:设备疗法:新适应症和未来方向

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摘要

Implantable cardioverter-defibrillator (ICDs), cardiac resynchronization (CRT) and combination (CRT-D) therapy have be-come an integral part of the management of patients with heart failure with reduced ejection fraction (HFrEF). ICDs treat ventricular arrhythmia and CRTs improve left ventricular systolic function by resynchronizing ventricular contraction. De-vice therapies (ICD, CRT-D), have been shown to reduce all-cause mortality, including sudden cardiac death. Hospitaliza-tions are reduced with CRT and CRT-D therapy. Major device related complications include device infection, inappropriate shocks, lead malfunction and complications related to extraction of devices. Improvements in device design and implantation have included progressive miniaturization and increasing battery life of the device, optimization of response to CRT, and minimizing inappropriate device therapy. Additionally, better definition of the population with the greatest benefit is an area of active research.
机译:植入式心脏复律除颤器(ICD),心脏再同步化(CRT)和联合治疗(CRT-D)治疗已成为射血分数降低(HFrEF)的心力衰竭患者治疗不可或缺的一部分。 ICD治疗室性心律失常,CRT通过重新同步心室收缩来改善左室收缩功能。辅助疗法(ICD,CRT-D)已被证明可以降低全因死亡率,包括心脏性猝死。 CRT和CRT-D治疗可减少住院。与设备有关的主要并发症包括设备感染,不当电击,导线故障以及与设备拔出有关的并发症。设备设计和植入方面的改进包括逐步小型化和增加设备的电池寿命,优化对CRT的反应以及最大程度地减少不合适的设备治疗。另外,对具有最大利益的人群进行更好的定义是积极研究的领域。

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