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Geraniin extracted from the rind of Nephelium lappaceum binds to dengue virus type-2 envelope protein and inhibits early stage of virus replication

机译：从兰phe的外皮中提取的香叶菊素与登革热病毒2型包膜蛋白结合并抑制病毒复制的早期阶段

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摘要

BackgroundThe rapid rise and spread in dengue cases, together with the unavailability of safe vaccines and effective antiviral drugs, warrant the need to discover and develop novel anti-dengue treatments. In this study the antiviral activity of geraniin, extracted from the rind of Nephelium lappaceum, against dengue virus type-2 (DENV-2) was investigated.

机译：背景登革热病例的迅速蔓延和扩散，以及缺乏安全疫苗和有效的抗病毒药物，都需要发现和开发新型的抗登革热治疗方法。在这项研究中，研究了从小叶猪phe皮提取的香叶素对2型登革热病毒（DENV-2）的抗病毒活性。

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期刊名称 Virology Journal
作者
Siti Aisyah Abdul Ahmad; Uma D. Palanisamy; Bimo A. Tejo; Miaw Fang Chew; Hong Wai Tham; Sharifah Syed Hassan;
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作者单位

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年(卷),期 2017(14),-1
年度 2017
页码 229
总页数 13
原文格式 PDF
正文语种
中图分类人体病毒学（致病病毒）;病毒（滤过性病毒）;
关键词
Antiviral DENV-2 E protein Geraniin Nephelium lappaceum;

机译：抗病毒;DENV-2 E蛋白;香叶菊酯;l;

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专利

1. Geraniin extracted from the rind of Nephelium lappaceum binds to dengue virus type-2 envelope protein and inhibits early stage of virus replication [J] . Siti Aisyah Abdul Ahmad, Uma D. Palanisamy, Bimo A. Tejo, Virology Journal . 2017,第1期

机译：从兰phe的外皮中提取的香叶素与登革热病毒2型包膜蛋白结合并抑制病毒复制的早期阶段
2. Mutation of the dengue virus type 2 envelope protein heparan sulfate binding sites or the domain III lateral ridge blocks replication in Vero cells prior to membrane fusion [J] . RoehrigJ.T., ButrapetS., LissN.M., Virology . 2013,第2期

机译：膜融合之前，登革热病毒2型包膜蛋白硫酸乙酰肝素结合位点或结构域III侧脊的突变会阻止Vero细胞中的复制
3. Posaconazole inhibits dengue virus replication by targeting oxysterol-binding protein [J] . Meutiawati Febrina, Bezemer Bodine, Strating Jeroen R. P. M., Antiviral Research . 2018,第期

机译：posaconazole通过靶向氧食醇结合蛋白来抑制登革热病毒复制
4. Identification of natural products as an inhibitor of β-OG pocket binder of dengue virus envelope protein using fragment-based drug design and molecular docking approach [C] . U. S. F. Tambunan, A. H. Alkaff International Symposium on Current Progress in Mathematics and Sciences . 2018

机译：用基于片段的药物设计和分子对接方法鉴定天然产物作为登革热病毒包膜蛋白β-OG口袋粘合剂的抑制剂
5. Mutagenesis of the dengue virus envelope glycoprotein gene can significanltly alter virus infectivity phenotypes in cultured cells and live mosquitoes. [D] . Erb, Steven Michael. 2011

机译：登革热病毒包膜糖蛋白基因的诱变可以显着改变培养细胞和活蚊子中的病毒感染性表型。
6. The Kinase Inhibitor SFV785 Dislocates Dengue Virus Envelope Protein from the Replication Complex and Blocks Virus Assembly [O] . Azlinda Anwar, Takamitsu Hosoya, Kok Mun Leong, 2008

机译：激酶抑制剂SFV785使复制复合物中的登革热病毒包膜蛋白脱位并阻止病毒装配
7. Geraniin extracted from the rind of Nephelium lappaceum binds to dengue virus type-2 envelope protein and inhibits early stage of virus replication [O] . Siti Aisyah Abdul Ahmad, Uma D.Palanisamy, Tejo Bimo A., 2017

机译：从兰phe的外皮中提取的香叶菊素与登革热2型包膜蛋白结合并抑制病毒复制的早期阶段

Geraniin extracted from the rind of Nephelium lappaceum binds to dengue virus type-2 envelope protein and inhibits early stage of virus replication

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