Respiratory Infections: 140 Inhibition of AKT Kinase Activity Decreases Replication of Human Respiratory Syncytial Virus

摘要

BackgroundHuman Respiratory Syncytial Virus (RSV) is a leading cause of pediatric pulmonary disease and severe RSV infection predisposes to wheezing later in life. RSV infection has also been shown to be an environmental trigger for asthma. We are investigating whether targeting host factors important for RSV infection is a viable antiviral strategy. Lowering viral burden through these therapies will result in decreased severity of infection and may also prevent the occurrence of pathologic sequelae.