Bacillus clausii as adjunctive treatment for acute community-acquired diarrhea among Filipino children: a large-scale multicenter open-label study (CODDLE)

摘要

BackgroundDiarrhea is among the main causes of pediatric mortality in the Philippines. Probiotics have been shown to be beneficial in the management of acute diarrhea. Accordingly, the aim of this population-based study was to assess the safety and effectiveness of Bacillus clausii as an adjunct to standard therapy in Filipino children with acute community-acquired diarrhea of viral origin or associated with antibiotic administration.