Combination leflunomide and methotrexate in refractory rheumatoid arthritis: a biologic sparing approach

机译：来氟米特和甲氨蝶呤联合治疗难治性类风湿关节炎：生物保护方法

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Background:In resource-constrained settings where biologic agents are not widely available, there are limited therapeutic options for patients with rheumatoid arthritis (RA) refractory to other synthetic disease modifying antirheumatic (DMARD) therapies. The aim of this study is to evaluate the effectiveness and safety of leflunomide (LEF) with methotrexate (MTX) in refractory RA.

机译：背景：在资源匮乏的环境中，无法广泛使用生物制剂，对于风湿性关节炎（RA）对其他合成抗风湿病（DMARD）疗法无效的患者，治疗选择有限。这项研究的目的是评估来氟米特（LEF）和甲氨蝶呤（MTX）在难治性RA中的有效性和安全性。

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期刊名称 Therapeutic Advances in Musculoskeletal Disease
作者
Bridget Hodkinson; Kingsley Ross Magomero; Mohammed Tikly;
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作者单位

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年(卷),期 2016(8),5
年度 2016
页码 172–179
总页数 8
原文格式 PDF
正文语种
中图分类外科学;
关键词
leflunomide rheumatoid arthritis sDMARD;

机译：来氟米特;类风湿关节炎;sDMARD;

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专利

1. Combination leflunomide and methotrexate in refractory rheumatoid arthritis: a biologic sparing approach [J] . Bridget Hodkinson, Kingsley Ross Magomero, Mohammed Tikly Therapeutic advances in musculoskeletal disease. . 2016,第5期

机译：来氟米特和甲氨蝶呤联合治疗难治性类风湿关节炎：生物保护方法
2. Leflunomide is equally efficacious and safe compared to low dose rituximab in refractory rheumatoid arthritis given in combination with methotrexate: results from a randomized double blind controlled clinical trial [J] . Harindu Wijesinghe, Priyadharshini Galappatthy, Rajiva de Silva, BMC Musculoskeletal Disorders . 2017,第1期

机译：与低剂量利妥昔单抗联合甲氨蝶呤治疗难治性类风湿性关节炎相比，来氟米特同样有效且安全：一项随机双盲对照临床试验的结果
3. Efficacy and safety of leflunomide alone and in combination with methotrexate in the treatment of refractory rheumatoid arthritis. [J] . Antony T, Jose VM, Paul BJ, Indian journal of medical sciences. . 2006,第8期

机译：来氟米特单独或与甲氨蝶呤联用治疗难治性类风湿关节炎的疗效和安全性。
4. Inflammatory gene profile in early rheumatoid arthritis and odulation by leflunomide and prednisone treatment [C] . Mgurizio Cutolo, Barbara Villaggio, Carmen Pizzorni, International Conference on the Neuroendocrine Immune Basis of the Rheumatic Diseases . 2010

机译：早期类风湿性关节炎和偏血清血清血清炎和泼尼松治疗的炎症基因谱
5. Development and characterization of methotrexate loaded poly(L-lactic acid) microspheres for the treatment of rheumatoid arthritis. [D] . Liang, Sanching Linda. 2006

机译：甲氨蝶呤负载聚（L-乳酸）微球的开发和表征，用于治疗类风湿关节炎。
6. Leflunomide is equally efficacious and safe compared to low dose rituximab in refractory rheumatoid arthritis given in combination with methotrexate: results from a randomized double blind controlled clinical trial [O] . Harindu Wijesinghe, Priyadharshini Galappatthy, Rajiva de Silva, 2017

机译：与低剂量利妥昔单抗联合甲氨蝶呤治疗难治性类风湿关节炎相比来氟米特同样有效且安全：一项随机双盲对照临床试验的结果
7. Combination leflunomide and methotrexate in refractory rheumatoid arthritis: a biologic sparing approach [O] . Bridget Hodkinson, Kingsley Ross Magomero, Mohammed Tikly 2016

机译：组合Leflunomide和甲氨蝶呤在难治性类风湿性关节炎：一种生物学备件方法

Combination leflunomide and methotrexate in refractory rheumatoid arthritis: a biologic sparing approach

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