BackgroundAdverse transfusion reactions in the neonatal population are poorly understood and defined. The incidence and pattern of adverse effects due to red blood cell (RBC) transfusion are not well known, and there has been no systematic review of published adverse events. RBC transfusions continue to be linked to the development of morbidities unique to neonates, including chronic lung disease, retinopathy of prematurity, intraventricular haemorrhage and necrotising enterocolitis. Uncertainties about the exact nature of risks alongside benefits of RBC transfusion may contribute to evidence of widespread variation in neonatal RBC transfusion practice.Our review aims to describe clinical adverse effects attributed to small-volume (10–20 mL/kg) RBC transfusions and, where possible, their incidence rates in the neonatal population through the systematic identification of all relevant studies.
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机译：背景新生儿人群中的不良输血反应知之甚少。由于红细胞（RBC）输注引起的不良反应的发生率和方式尚不十分清楚，并且尚未对已发表的不良事件进行系统的审查。 RBC输血继续与新生儿所特有的疾病发展有关，包括慢性肺病，早产儿视网膜病变，脑室内出血和坏死性小肠结肠炎。风险的确切性质以及RBC输注的益处的不确定性可能会导致新生儿RBC输注实践广泛变化的证据。我们的综述旨在描述小剂量（10–20 mL / kg）RBC输注引起的临床不良反应，以及通过对所有相关研究的系统鉴定，尽可能确定其在新生儿人群中的发生率。
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