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Co-overexpression of TGF-β and SOX9 via rAAV gene transfer modulates the metabolic and chondrogenic activities of human bone marrow-derived mesenchymal stem cells

机译：通过rAAV基因转移共转化TGF-β和SOX9可调节人骨髓间充质干细胞的代谢和软骨形成活性

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BackgroundArticular cartilage has a limited potential for self-healing. Transplantation of genetically modified progenitor cells like bone marrow-derived mesenchymal stem cells (MSCs) is an attractive strategy to improve the intrinsic repair capacities of damaged articular cartilage.

机译：背景关节软骨具有自我修复的潜力。基因修饰的祖细胞（如骨髓间充质干细胞（MSC））的移植是提高受损关节软骨固有修复能力的有吸引力的策略。

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期刊名称 Stem Cell Research Therapy
作者
Ke Tao; Janina Frisch; Ana Rey-Rico; Jagadeesh K. Venkatesan; Gertrud Schmitt; Henning Madry; Jianhao Lin; Magali Cucchiarini;
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作者单位

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年(卷),期 2016(7),-1
年度 2016
页码 20
总页数 12
原文格式 PDF
正文语种
中图分类细胞生物学;医学史;
关键词
Human mesenchymal stem cells Recombinant adeno-associated virus Multiple gene transfer Transforming growth factor beta SOX9 Chondrogenesis;

机译：人间充质干细胞;重组腺相关病毒;多基因转移;转化生长因子β;SOX9;软骨形成;

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专利

1. Co-overexpression of TGF-β and SOX9 via rAAV gene transfer modulates the metabolic and chondrogenic activities of human bone marrow-derived mesenchymal stem cells [J] . Ke Tao, Janina Frisch, Ana Rey-Rico, Stem Cell Research & Therapy . 2016,第1期

机译：通过rAAV基因转移共转化TGF-β和SOX9，可调节人骨髓间充质干细胞的代谢和软骨形成活性
2. Effects of combined rAAV-mediated TGF-β and sox9 gene transfer and overexpression on the metabolic and chondrogenic activities in human bone marrow aspirates [J] . Ke Tao, Ana Rey-Rico, Janina Frisch, Journal of experimental orthopaedics. . 2017,第1期

机译：rAAV介导的TGF-β和sox9基因联合转移和过表达对人骨髓抽吸物代谢和软骨活性的影响
3. CHONDROGENIC DIFFERENTIATION PROCESSES IN HUMAN BONE MARROW-DERIVED MESENCHYMAL STEM CELLS UPON RAAV MEDIATED CO-OVEREXPRESSION OF TGF-B AND IGF-I [J] . Morscheid S., Rey-Rico A., Schmitt G., Osteoarthritis and cartilage . 2019,第Suppla1期

机译：在rav介导的TGF-B和IGF-1中raAv介导的人骨髓间充质干细胞中有软骨菌分化过程
4. Improved Chondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stromal Cells in a Spongiform Collagenous Scaffold [C] . Rudert M, Hoberg M, Hepperle T, Combined Meeting of the Orthopaedic Research Societies . 2011

机译：改善了骨髓衍生的间充质基质细胞在海绵状胶原屑中的软骨外分化
5. Growth and Differentiation Potential of Human Bone Marrow-derived Mesenchymal Stem Cells in Response to Dexamethasone and Selection for Collagen Adherence [D] . Weissman, Alexander Clemens. 2019

机译：人骨髓间充质干细胞对地塞米松的生长分化潜能及胶原粘附的选择
6. Effects of combined rAAV-mediated TGF-β and sox9 gene transfer and overexpression on the metabolic and chondrogenic activities in human bone marrow aspirates [O] . Ke Tao, Ana Rey-Rico, Janina Frisch, 2017

机译：rAAV介导的TGF-β和sox9基因联合转移和过表达对人骨髓抽吸物代谢和软骨活性的影响
7. Co-overexpression of TGF-β and SOX9 via rAAV gene transfer modulates the metabolic and chondrogenic activities of human bone marrow-derived mesenchymal stem cells [O] . Ke Tao, Janina Frisch, Ana Rey-Rico, 2016

机译：通过rAAV基因转移共转化TGF-β和SOX9，可调节人骨髓间充质干细胞的代谢和软骨形成活性

Co-overexpression of TGF-β and SOX9 via rAAV gene transfer modulates the metabolic and chondrogenic activities of human bone marrow-derived mesenchymal stem cells

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