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Decellularized human ovarian scaffold based on a sodium lauryl ester sulfate (SLES)-treated protocol as a natural three-dimensional scaffold for construction of bioengineered ovaries

机译:基于十二烷基硫酸钠(SLES)处理的协议的脱细胞人卵巢支架作为用于构建生物工程卵巢的天然三维支架

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摘要

BackgroundThe increasing number of patients with ovarian insufficiency due to autoimmune disorders, genetic predisposition, or iatrogenic effects of treatment such as cancer therapies necessitates an urgent measure to find a safe and transplantable alternative ovary. A bioengineered ovary is one of the strategies on which the researchers have recently been working. An engineered ovary should be able to mimic the natural ovary aspects. Recent studies suggest that the decellularized organ-specific extracellular matrix-based scaffolds can serve as a native niche to bioengineering artificial organs. Therefore, we established a human decellularized ovarian scaffold based on a sodium lauryl ester sulfate (SLES)-treated process, as an optimized protocol.
机译:背景技术由于自身免疫性疾病,遗传易感性或医源性治疗(例如癌症治疗)导致的卵巢功能不全患者的数量不断增加,因此迫切需要找到安全且可移植的替代卵巢的措施。生物工程卵巢是研究人员最近正在研究的策略之一。工程卵巢应该能够模仿自然的卵巢状况。最近的研究表明,脱细胞的器官特异性细胞外基质为基础的支架可以作为生物工程人工器官的天然利基。因此,我们建立了基于十二烷基硫酸钠硫酸钠(SLES)处理过的人类脱细胞卵巢支架,作为优化方案。

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