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Plasmonic Nanomaterial-Based Optical Biosensing Platforms for Virus Detection

机译:基于等离子纳米材料的光学生物传感平台用于病毒检测

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摘要

Plasmonic nanomaterials (P-NM) are receiving attention due to their excellent properties, which include surface-enhanced Raman scattering (SERS), localized surface plasmon resonance (LSPR) effects, plasmonic resonance energy transfer (PRET), and magneto optical (MO) effects. To obtain such plasmonic properties, many nanomaterials have been developed, including metal nanoparticles (MNP), bimetallic nanoparticles (bMNP), MNP-decorated carbon nanotubes, (MNP-CNT), and MNP-modified graphene (MNP-GRP). These P-NMs may eventually be applied to optical biosensing systems due to their unique properties. Here, probe biomolecules, such as antibodies (Ab), probe DNA, and probe aptamers, were modified on the surface of plasmonic materials by chemical conjugation and thiol chemistry. The optical property change in the plasmonic nanomaterials was monitored based on the interaction between the probe biomolecules and target virus. After bioconjugation, several optical properties, including fluorescence, plasmonic absorbance, and diffraction angle, were changed to detect the target biomolecules. This review describes several P-NMs as potential candidates of optical sensing platforms and introduces various applications in the optical biosensing field.
机译:等离子体纳米材料(P-NM)由于其优异的性能而受到关注,包括表面增强拉曼散射(SERS),局部表面等离子体激元共振(LSPR)效应,等离子体共振能量转移(PRET)和磁光(MO)效果。为了获得这种等离子体性能,已经开发了许多纳米材料,包括金属纳米颗粒(MNP),双金属纳米颗粒(bMNP),MNP装饰的碳纳米管(MNP-CNT)和MNP修饰的石墨烯(MNP-GRP)。这些P-NM由于其独特的性能最终可以应用于光学生物传感系统。在此,通过化学结合和硫醇化学修饰等离激元材料表面上的探针生物分子,例如抗体(Ab),探针DNA和探针适体。基于探针生物分子和目标病毒之间的相互作用,监测了等离子体纳米材料的光学性质变化。生物缀合后,包括荧光,等离子体吸收度和衍射角在内的几种光学性质都发生了变化,以检测目标生物分子。这篇综述描述了几种P-NM作为光学传感平台的潜在候选对象,并介绍了光学生物传感领域的各种应用。

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