191. Independent Contributions of Early Adolescent Delusion-Like Experiences and Hallucination-Like Experiences to Poorer Psychological Outcomes and Global Functioning in Mid-Adolescence: Longitudinal Cohort Study.

摘要

>Background: It is well established that young adolescents are particularly susceptible to subclinical psychotic-like experiences (PLEs). These experiences have been linked to an increased risk of lifetime development a mental health disorder. PLE’s consist of a variety of experiences and there is little research investigating which subtype of PLEs contributes to the development of psychopathology and poorer global functioning. >Methods: We followed a cohort from early to mid-adolescence to investigate whether endorsing PLE symptoms in early adolescence is related to poorer psychosocial functioning in mid adolescence. At T1, 212 of the participants (mean age: 11.5 years) who participated in the “Adolescent Brain Development” study and completed the Adolescent Psychotic Symptoms Screener (APSS). Factor analysis was conducted on APSS scores and identified two clear independent factors; Hallucination-Like Experiences (HLEs) and Delusion-Like Experiences (DLEs). 86 took part in a second phase (T2) of the study (mean age: 15.7yrs). At T2, participants were administered the Youth Self Report questionnaire (YSR; Total score, internalized and externalized scores) and were assessed on the Global assessment of functioning scale (GAF-current and GAF-most severe past). Regression analysis was used to investigate the independent contributions of T1 factors (HLEs and DLEs) on participant’s psychological well-being (YSR) and general functioning (GAF) at T2. >Results: The results indicated that HLEs, but not DLEs, contributed to T2 YSR Total Score (r² = .219, P = .002) and Internalizing Score (r² = .113, P = .019). HLEs contribute more than DLEs to Externalizing Score (r² = .127, P = .002 and r² = .067, P = .047, respectively). However, DLEs made a greater contribution to GAF current scores (DLEs: r² = .146, P  = .001; and HLEs: r² = .059, P = .028) and DLE’s were the only significant predictor of GAF most severe past scores (r² = .113, P = .002). >Conclusion: These results indicate divergent roles for HLE’s and DLE’s in the development of poor psychosocial functioning in mid-adolescence. Early adolescent HLEs increase vulnerability to mid-adolescent internalizing and externalizing behavioral problems. Interestingly, DLEs appear to contribute to poorer global functioning (e.g., distress at symptoms and poor social functioning). Therefore, these experiences should be considered as independent markers when evaluating risk of psychopathology in young people.