Extended report: A new classification of HLA-DRB1 alleles based on acid–base properties of the amino acids located at positions 13 70 and 71: impact on ACPA status or structural progression and meta-analysis on 1235 patients with rheumatoid from two cohorts (ESPOIR and EAC cohort)

摘要

ObjectiveTo group HLA-DRB1 alleles based on acid–base properties of amino acids at positions 13, 70 and 71 and analyse their association with the presence of anticitrullinated peptide antibodies (ACPA) and structural progression in 2 cohorts of early rheumatoid arthritis (RA).